Northwestern University Feinberg School of Medicine

Northwestern University Prosthetics-Orthotics Center

Interface Monitoring System to Promote Residual Limb Health

Co-Principal Investigators:Yonggang Huang and Stefania Fatone (Northwestern University); Todd Coleman (UCSD); and John Rogers (Northwestern University)

Co-Investigators: Lilly Tran, MS; Ryan Caldwell, CP

Funded by: Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) and National Institute of Biomedical Imaging and Bioengineering (NIBIB) 5R01EB019337

Status: In Progress

Project Overview

This proposal aims to develop a stretchable and flexible sensor technology capable of transforming healthcare from reactive and hospital-centered to preventive, proactive, evidence-based, and person-centered. The goal is to offer ‘skin-like’ properties, to enable intimate, complete non-invasive integration with the patient. The resulting ‘epidermal’ electronic devices (Kim, Lu et al. 2011) may allow clinicians to monitor their patients, and the general public to assess, continuously, their health and wellbeing. The proposed interface monitoring system, designed to promote residual limb health in persons who wear prostheses, in physical forms that are skin-like, may demonstrate key technological and scientific advancements towards evidenced-based and person-centered prosthetic care.

The work involves collaboration across three institutions to:

The proposed work will improve health by leading development of new biomedical imaging devices for early detection and prevention of health problems and assessment of health status. In addition to prosthetic care, the proposal may address an unmet need for a model system for individualized healthcare, in which continuous sensing, monitoring and assessment are performed using wireless epidermal sensors instead of traditional lab-based instrumentation.

Progress Update

Focus Groups Used to Gather Stakeholder Input

As a first step in ensuring the clinical relevance and usefulness of the proposed development work, we convened two focus groups, one group consisting of Certified Prosthetists and one group of lower-limb prosthesis users, to gather input on system configuration and data presentation. The focus groups were held at NUPOC on January 21 and March 16 2015, respectively. The very fruitful discussions were recorded and currently are being transcribed for further analysis.

References

Kim, D. H., N. Lu, R. Ma, Y. S. Kim, R. H. Kim, S. Wang, J. Wu, S. M. Won, H. Tao, A. Islam, K. J. Yu, T. I. Kim, R. Chowdhury, M. Ying, L. Xu, M. Li, H. J. Chung, H. Keum, M. McCormick, P. Liu, Y. W. Zhang, F. G. Omenetto, Y. Huang, T. Coleman and J. A. Rogers (2011). "Epidermal electronics." Science333(6044): 838-843.

Acknowledgements

NUPOC would like to acknowledge the support of Ottobock in providing two residual limb models for use in this project.

NUPOC would like to thank the prosthetists and prosthesis users who participated in our focus groups for their candid and helpful comments. We also would like to acknowledge research extern, Matthew Quigley, for his invaluable help in preparing for the focus groups. Additionally, we thank Dr. R. J. Garrick for moderating, Piper Kruse for audio recordings, and Linda India for support with catering and administration.

Publications

Zhang Y, Webb RC, Luo H, Xue Y, Kurniawan J, Cho NH, Krishnan S, Li Y, Huang Y, and Rogers JA (2016) Theoretical and Experimental Studies of Epidermal Heat Flux Sensors for Measurements of Core Body Temperature. Adv. Healthcare Mater. 2016, 5, 119–127.

Presentations

Tran L, Han S, Caldwell R, Rogers J, Coleman T, Fatone S (2017) Ability of Epidermal Sensors to Measure Lower-Limb Temperature during Activity with a Prosthesis Simulator. The 43rd Academy Annual Meeting & Scientific Symposium of the American Academy of Orthotists & Prosthetists (AAOP), March 1-4, Chicago, IL. 

Fatone S, Caldwell R (2016) Socket-Related Research Collaborations at Northwestern University. Scheck Fair. April 8-9, Lombard, Illinois.

Tran L, Caldwell R, Quigley M, Fatone S (2016) Stakeholder Input on the Development of a Residual Limb Monitoring System. 12th Annual Lewis Landsberg Research Day, April 7, Northwestern University, Chicago, IL (poster). 

Tran L, Caldwell R, Quigley M, Fatone S (2016) Stakeholder Input on a Residual Limb Monitoring System. 42nd American Academy of Orthotists and Prosthetists Annual Meeting & Scientific Symposium, March 9-11, Orlando, FL.

Tran L, Caldwell R, Quigley M, Fatone S (2016) Stakeholder Input on Development of a Residual Limb Health Monitoring System. NUPOC Biennial Symposium for the German-Speaking Travel Fellows of Initiative ’93, February 25, Chicago, Illinois. 

Tran L, Han S, Caldwell R, Rogers J, Coleman T, Fatone S (2016) Ability of epidermal sensors to measure lower limb temperature during activity with a prosthesis simulator. Midwest Chapter of the American Academy of Orthotists and Prosthetists, November 3-5, Rosemont, IL.

Tran L, Fatone S, Caldwell R (2015) Stakeholder Input on Development of a Residual Limb Health Monitoring System. Midwest Chapter, American Academy of Orthotists and Prosthetists Annual Meeting and Scientific Session, May 27-29, Rosemont, IL.

Fatone S, Huang Y, Rogers J, Coleman T, Tran L (2015) Interface Monitoring System to Promote Residual Limb Health. Ignite Talk at the 2015 NSF Smart and Connected Health (SCH) Principal Investigators Workshop: Amplifying Discovery through Shared Resources and Defining and Measuring Health Impact in SCH Research, June 30-July 1, 2015, Arlington, VA. [Access PDF, see Section #57, pages 115-120.]

Fatone S, Huang Y, Coleman T, Rogers J, Banks A, Tran L, Caldwell R, Brown D, Pharr M (2015) Interface Monitoring System to Promote Residual Limb Health (poster). 2015 NSF Smart and Connected Health (SCH) Principal Investigators Workshop: Amplifying Discovery through Shared Resources and Defining and Measuring Health Impact in SCH Research, June 30-July 1, 2015, Arlington, VA.

Leitner Tammy and Capitanini Lisa. Human Body Merges with Technology in 'Biohacking' Trend, NBC 5, Chicago, IL (Published Monday, Sept. 21, 2015).

Related Publications

Clark V. (March 2017) O&P Research Supports Evidence-based Care. The O&P Edge, 16(3):20-34. http://www.oandp.com/articles/2017-03_01.asp

Co-principal Investigator, John Rogers, to Join Northwestern University

Co-principal investigator, collaborator and innovator, John Rogers, will join Northwestern University in autumn 2016 as the Louis Simpson and Kimberly Querrey Professor of Materials Science and Engineering, Biomedical Engineering and Medicine. 

Monitoring Limb Health

Signals from skin-like sensors can be wirelessly monitored

Signals from skin-like sensors are wirelessly monitored